Iodine → HCID 66905241, compound

HRID 1690597Notes

Reaction equation

HRID 1690597 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:6]=[CH:7][CH:8]=1)[NH2:5].[F:9][C:10]1[C:17]([F:18])=[CH:16][C:13]([CH:14]=O)=[C:12]([N+:19]([O-])=O)[CH:11]=1.[O-]S([O-])(=O)=O.[Na+].[Na+].[In].II>>[Cl:1][C:2]1[CH:3]=[C:4]([NH:5][C:14]2[N:5]([C:4]3[CH:6]=[CH:7][CH:8]=[C:2]([Cl:1])[CH:3]=3)[N:19]=[C:12]3[C:13]=2[CH:16]=[C:17]([F:18])[C:10]([F:9])=[CH:11]3)[CH:6]=[CH:7][CH:8]=1

Participants

6

Reactant 5

HCID 807IodineHCID 79323-ChloroanilineHCID 24436Sodium SulfateHCID 5359967IndiumHCID 199572974,5-Difluoro-2-nitrobenzaldehyde

Product 1

HCID 66905241HCID 66905241, compound

Procedure

In analogy to the procedure described in example 35.1, 3-chloroaniline was reacted with 4,5-difluoro-2-nitro-benzaldehyde (Daubie, Christophe; Legrand, Jean Jacques; Pemberton, Clive. Eur. Pat. Appl. (1993), EP 538 100 A1) in the presence of Na2SO4, indium and iodine to give the title compound as brown solid. MS: m/e=388.0 [M−H−].

Sources & evidence

ORD record
ord-ba2caa7f8b814ad6ae99aef1338a3e6c
Source dataset
uspto-grants-2012_04
Patent number
US08153663B2

Reaction notes

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