1-oxo-2,3-dihydro-1H-indene-5-carbonitrile → HCID 16046755, compound

HRID 1690684Notes

Reaction equation

HRID 1690684 reaction equation
O=[C:2]1[C:10]2[C:5](=[CH:6][C:7]([C:11]#[N:12])=[CH:8][CH:9]=2)[CH2:4][CH2:3]1.Cl.[CH2:14]([C:18]1[CH:23]=[CH:22][C:21]([C:24]2[CH:29]=[CH:28][CH:27]=[C:26]([NH:30]N)[C:25]=2[F:32])=[CH:20][CH:19]=1)[CH2:15][CH2:16][CH3:17]>>[CH2:14]([C:18]1[CH:19]=[CH:20][C:21]([C:24]2[CH:29]=[CH:28][C:27]3[C:3]4[CH2:4][C:5]5[C:10](=[CH:9][CH:8]=[C:7]([C:11]#[N:12])[CH:6]=5)[C:2]=4[NH:30][C:26]=3[C:25]=2[F:32])=[CH:22][CH:23]=1)[CH2:15][CH2:16][CH3:17]

Participants

3

Reactant 2

HCID 3128961-oxo-2,3-dihydro-1H-indene-5-carbonitrileHCID 66904900HCID 66904900, compound

Product 1

HCID 16046755HCID 16046755, compound

Procedure

A sample of 1-oxo-indan-5-carbonitrile (133.5 mg, 0.85 mmol) (Example 74, step 1) and (4′-Butyl-2-fluoro-biphenyl-3-yl)-hydrazine hydrochloride (250.4, 0.85 mmol) are reacted together as in example 1, step 3 followed by purification by UV triggered reverse phase HPLC to afford the title compound as a white solid. LC/MS calculated for [M+H]+ C26H21FN2: 381.2, found: 381.2.

Workup

  1. customfollowed by purification by UV triggered reverse phase HPLC

Sources & evidence

ORD record
ord-c56e5d857d0b4b2e96f5357ebc68483d
Source dataset
uspto-grants-2012_04
Patent number
US08153671B2

Reaction notes

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