Hydracrylonitrile → HCID 24991230, compound

HRID 1690837Notes

Reaction equation

[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([Cl:8])=[CH:4][C:3]=1[CH:9]([CH2:12][OH:13])[C:10]#[N:11].[OH:14][CH2:15][CH2:16]C#N>>[C:15]([O:13][CH2:12][CH:9]([C:3]1[CH:4]=[C:5]([Cl:8])[CH:6]=[CH:7][C:2]=1[Cl:1])[C:10]#[N:11])(=[O:14])[CH3:16]

Participants

Reactant 2

HCID 8011Hydracrylonitrile

HCID 66905936HCID 66905936, compound

Product 1

HCID 24991230HCID 24991230, compound

Procedure

This ester was prepared using the procedure described in Example 5, except 2-(2,5-dichlorophenyl)-3-hydroxypropanenitrile was used in place of 2-(2-chloro-5-(difluoromethoxy)phenyl)-3-hydroxypropanenitrile. The preparation of 2-2,5-dichlorophenyl)-3-hydroxypropanenitrile is described in Example 4. The recovered ester product was a white solid (92% yield), m.p. 79-80.5° C.

Sources & evidence

ORD record: ord-683ca67a6e5b45eb8f105677358781c2
Source dataset: uspto-grants-2012_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08153688B2

Reaction notes

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