Ethyl Acetate → HCID 24991585, compound

HRID 1690839Notes

Reaction equation

HRID 1690839 reaction equation
[F:1][C:2]([F:15])([F:14])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[CH:9]([CH2:12][OH:13])[C:10]#[N:11].[C:16](OCC)(=[O:18])[CH3:17]>CCCCCC>[C:16]([O:13][CH2:12][CH:9]([C:4]1[CH:5]=[CH:6][CH:7]=[CH:8][C:3]=1[C:2]([F:14])([F:15])[F:1])[C:10]#[N:11])(=[O:18])[CH3:17]

Participants

4

Reactant 2

HCID 8857Ethyl AcetateHCID 63215470HCID 63215470, compound2×

Product 1

HCID 24991585HCID 24991585, compound

Reagents, catalysts & solvents 1

HCID 8058HexaneSolvent

Procedure

This ester was prepared using the procedure described in Example 5, except 2-(2-(trifluoromethyl)phenyl)-3-hydroxypropanenitrile was used in place of 2-(2-chloro-5-(difluoromethoxy)phenyl)-3-hydroxypropanenitrile. The preparation of 2-(2-(trifluoromethyl)phenyl)-3-hydroxypropanenitrile is described in Example 9. The recovered ester product was a colorless oil (95% yield), Rf 0.35 (silica gel, ethyl acetate:hexane=1:4).

Sources & evidence

ORD record
ord-8276eac01d2242589c9089bd381ea840
Source dataset
uspto-grants-2012_04
Patent number
US08153688B2

Reaction notes

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