Acetic Anhydride → HCID 66906227, compound

HRID 1690853Notes

Reaction equation

HRID 1690853 reaction equation
[OH:1][CH2:2][CH:3]([C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([O:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[CH:7]=1)[C:4]#[N:5].[C:19](OC(=O)C)(=[O:21])[CH3:20]>C(#N)C>[C:19]([O:1][CH2:2][CH:3]([C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([O:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[CH:7]=1)[C:4]#[N:5])(=[O:21])[CH3:20]

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 13558941HCID 13558941, compound

Product 1

HCID 66906227HCID 66906227, compoundYield 86%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

A 175 mg (0.738 mmol) sample of the above 3-hydroxy-2-(3-phenoxyphenyl)propanenitrile was acylated with acetic anhydride (74 μL) in acetonitrile (300 μL) using the procedure described in Example 5 to give 147 mg (86% yield) of 3-acetoxy-2-(3-phenoxyphenyl)propanenitrile as a colorless oil.

Sources & evidence

ORD record
ord-5d8efaf9f1c44cfaa8d660e6c492ee8f
Source dataset
uspto-grants-2012_04
Patent number
US08153688B2

Reaction notes

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