反应详情

To an anhydrous tetrahydrofuran (25 mL) solution of 4-((E)-2-furan-2-yl-vinyl)benzoic acid ethyl ester (1.07 g, 4.4 mmol) described in Manufacturing Example 80-1-1 was added 10% palladium-carbon (50% hydrate, 500 mg), which was added for 2 hours under a hydrogen atmosphere at room temperature. The reaction product was filtered, and the filtrate was concentrated under a reduced pressure. The residue was purified by silica gel column chromatography (t-butylmethyl ether:heptane=5:95) to obtain the title compound (706 mg, 65.4%).

1. additionwas added for 2 hours under a hydrogen atmosphere at room temperature
2. filtrationThe reaction product was filtered
3. concentrationthe filtrate was concentrated under a reduced pressure
4. customThe residue was purified by silica gel column chromatography (t-butylmethyl ether:heptane=5:95)