2-Hydroxy-4-nitrobenzyl alcohol → 2-Hydroxy-4-nitrobenzaldehyde

HRID 1691615Notes

Reaction equation

HRID 1691615 reaction equation
[OH:1][CH2:2][C:3]1[CH:8]=[CH:7][C:6]([N+:9]([O-:11])=[O:10])=[CH:5][C:4]=1[OH:12]>C(Cl)(Cl)Cl.[O-2].[Mn+4].[O-2]>[OH:12][C:4]1[CH:5]=[C:6]([N+:9]([O-:11])=[O:10])[CH:7]=[CH:8][C:3]=1[CH:2]=[O:1]

Participants

4

Reactant 1

HCID 118160942-Hydroxy-4-nitrobenzyl alcohol

Product 1

HCID 755702-Hydroxy-4-nitrobenzaldehyde

Reagents, catalysts & solvents 2

HCID 178418406HCID 178418406, compoundCatalystHCID 6212ChloroformSolvent

Procedure

6.0 g (35.5 mmol) of 2-(hydroxymethyl)-5-nitrophenol and 3.1 g (35.5 mmol) of activated manganese(IV) oxide in 100 ml of chloroform are heated under reflux for 20 h. The mixture is filtered through kieselguhr, concentrated and dried under high vacuum. The title compound is immediately reacted further.

Workup

  1. temperatureunder reflux for 20 h
  2. filtrationThe mixture is filtered through kieselguhr
  3. concentrationconcentrated
  4. customdried under high vacuum
  5. customThe title compound is immediately reacted further

Sources & evidence

ORD record
ord-fb9b9904369d4cc5a61f7be55577c6e1
Source dataset
uspto-grants-2012_04
Patent number
US08153799B2

Reaction notes

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