1,4-Dioxane hydrochloride → HCID 86638696, compound

HRID 1691676Notes

Reaction equation

HRID 1691676 reaction equation
[C:1]1([C@H:11]([NH:13][CH2:14][CH:15]2[CH:20]([C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=3)[CH2:19][CH2:18][N:17]([C:27](=[O:32])[C:28]([F:31])([F:30])[F:29])[CH2:16]2)[CH3:12])[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][CH:2]=1.[ClH:33].O1CCOCC1>C(O)C>[ClH:33].[C:1]1([C@H:11]([NH:13][CH2:14][CH:15]2[CH:20]([C:21]3[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=3)[CH2:19][CH2:18][N:17]([C:27](=[O:32])[C:28]([F:29])([F:30])[F:31])[CH2:16]2)[CH3:12])[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][CH:2]=1

Participants

4

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 59178549HCID 59178549, compound

Product 1

HCID 86638696HCID 86638696, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

200 mg of (1R)-1-(1-naphthyl)-N-{[4-phenyl-1-(trifluoroacetyl)piperidin-3-yl]methyl}ethaneamine was dissolved in 4.0 mL of ethanol, and 300 μL of a 4 M hydrogen chloride/1,4-dioxane solution was added thereto at room temperature. After stirring for 5 min, the reaction mixture was concentrated under reduced pressure, and the residue was crystallized from isopropanol to obtain 173 mg of (1R)-1-(1-naphthyl)-N-{[4-phenyl-1-(trifluoroacetyl)piperidin-3-yl]methyl}ethaneamine hydrochloride as a white powder.

Workup

  1. customat room temperature
  2. concentrationthe reaction mixture was concentrated under reduced pressure
  3. customthe residue was crystallized from isopropanol

Sources & evidence

ORD record
ord-8d08f05c035c48208b3e60b2e462a680
Source dataset
uspto-grants-2012_04
Patent number
US08153658B2

Reaction notes

Loading…