1,4-Dioxane hydrochloride → HCID 86638696, compound

Participants

Reaction Steps

200 mg of (1R)-1-(1-naphthyl)-N-{[4-phenyl-1-(trifluoroacetyl)piperidin-3-yl]methyl}ethaneamine was dissolved in 4.0 mL of ethanol, and 300 μL of a 4 M hydrogen chloride/1,4-dioxane solution was added thereto at room temperature. After stirring for 5 min, the reaction mixture was concentrated under reduced pressure, and the residue was crystallized from isopropanol to obtain 173 mg of (1R)-1-(1-naphthyl)-N-{[4-phenyl-1-(trifluoroacetyl)piperidin-3-yl]methyl}ethaneamine hydrochloride as a white powder.

Provenance & Evidence