HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → (2-Bromo-5-difluoromethoxy-4-methoxy-phenyl)-acetic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Lithium Hydroxide | HCID 3939 | — |
| Reactant | (2-Bromo-5-difluoromethoxy-4-methoxy-phenyl)-acetic acid methyl ester | HCID 59377715 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Water | HCID 962 | — |
| Product | (2-Bromo-5-difluoromethoxy-4-methoxy-phenyl)-acetic acid | HCID 59377691 | 91.4% |
Reaction Steps
(2-Bromo-5-difluoromethoxy-4-methoxy-phenyl)-acetic acid methyl ester (400 mg) was dissolved in 5 ml methanol and treated with 150 mg lithium hydroxide in 1 ml of water. The mixture was stirred at room temperature for 18 hours, acidified with 10% aqueous hydrochloric acid, filtered and dried to yield 350 mg of (2-bromo-5-difluoromethoxy-4-methoxy-phenyl)-acetic acid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08153808B2 |
| Source dataset | uspto-grants-2012_04 |
| ORD ID | ord-6249229d6bec4948bc8fd12be3575e24 |
| Source note | uspto-grants-2012_04 |