1-Bromo-2-isocyanato-4-methoxy-5-methyl-benzene → 4-oxo-3,4-dihydro-2H-[2,3']bipyridinyl-1-carboxylic acid (2-bromo-5-methoxy-4-methyl-phenyl)-amide

HRID 1691834Notes

Reaction equation

HRID 1691834 reaction equation
[NH:1]1[CH:6]=[CH:5][C:4](=[O:7])[CH2:3][CH:2]1[C:8]1[CH:9]=[N:10][CH:11]=[CH:12][CH:13]=1.[Br:14][C:15]1[CH:20]=[C:19]([CH3:21])[C:18]([O:22][CH3:23])=[CH:17][C:16]=1[N:24]=[C:25]=[O:26]>>[Br:14][C:15]1[CH:20]=[C:19]([CH3:21])[C:18]([O:22][CH3:23])=[CH:17][C:16]=1[NH:24][C:25]([N:1]1[CH:6]=[CH:5][C:4](=[O:7])[CH2:3][CH:2]1[C:8]1[CH:9]=[N:10][CH:11]=[CH:12][CH:13]=1)=[O:26]

Participants

3

Reactant 2

HCID 593777511-Bromo-2-isocyanato-4-methoxy-5-methyl-benzeneHCID 593777842,3-dihydro-1H-[2,3']bipyridinyl-4-one

Product 1

HCID 593778044-oxo-3,4-dihydro-2H-[2,3']bipyridinyl-1-carboxylic acid (2-bromo-5-methoxy-4-methyl-phenyl)-amide

Procedure

2,3-Dihydro-1H-[2,3′]bipyridinyl-4-one was reacted with 1-bromo-2-isocyanato-4-methoxy-5-methyl-benzene using the procedure of step 3 of Example 1 to afford 4-oxo-3,4-dihydro-2H-[2,3′]bipyridinyl-1-carboxylic acid (2-bromo-5-methoxy-4-methyl-phenyl)-amide, MS (M+H) 417.

Sources & evidence

ORD record
ord-155a9b925ab84cc18b31bfcce713c943
Source dataset
uspto-grants-2012_04
Patent number
US08153809B2

Reaction notes

Loading…