(S)-2-(4-fluoro-phenyl)-2,3-dihydro-1H-pyridin-4-one → (S)-2-(4-fluoro-phenyl)-4-oxo-3,4-dihydro-2H-pyridine-1-carboxylic acid (2-isopropyl-4,5-dimethoxy-phenyl)-amide

HRID 1691847Notes

Reaction equation

HRID 1691847 reaction equation
[N:1]([C:4]1[CH:9]=[C:8]([O:10][CH3:11])[C:7]([O:12][CH3:13])=[CH:6][C:5]=1[CH:14]([CH3:16])[CH3:15])=[C:2]=[O:3].[F:17][C:18]1[CH:23]=[CH:22][C:21]([C@@H:24]2[CH2:29][C:28](=[O:30])[CH:27]=[CH:26][NH:25]2)=[CH:20][CH:19]=1>>[CH:14]([C:5]1[CH:6]=[C:7]([O:12][CH3:13])[C:8]([O:10][CH3:11])=[CH:9][C:4]=1[NH:1][C:2]([N:25]1[CH:26]=[CH:27][C:28](=[O:30])[CH2:29][C@H:24]1[C:21]1[CH:22]=[CH:23][C:18]([F:17])=[CH:19][CH:20]=1)=[O:3])([CH3:16])[CH3:15]

Participants

3

Reactant 2

HCID 59377679(S)-2-(4-fluoro-phenyl)-2,3-dihydro-1H-pyridin-4-oneHCID 593777751-Isocyanato-2-isopropyl-4,5-dimethoxy-benzene

Product 1

HCID 59377855(S)-2-(4-fluoro-phenyl)-4-oxo-3,4-dihydro-2H-pyridine-1-carboxylic acid (2-isopropyl-4,5-dimethoxy-phenyl)-amide

Procedure

1-Isocyanato-2-isopropyl-4,5-dimethoxy-benzene was reacted with (S)-2-(4-fluoro-phenyl)-2,3-dihydro-1H-pyridin-4-one following the procedure of step 3 of Example 1.

Sources & evidence

ORD record
ord-027e0c7191bf4978823e97e30caf6b99
Source dataset
uspto-grants-2012_04
Patent number
US08153809B2

Reaction notes

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