反应详情

温度

45 °C

Tenofovir disoproxil (2.5 gm) is dissolved in isopropyl alcohol (12.5 ml), fumaric acid (0.6 gm) is added at 25-30° C. and then the temperature is raised to 45° C., maintained for 20 minutes. The reaction mass is cooled to 25-30° C. and stirred for 1 hour at the same temperature and again mass is cooled to 0-5° C., stirred for 1 hour at 0-5° C. Filtered the material, washed with isopropyl alcohol (2 ml) and finally washed with hexane to give 2.4 gm of tenofovir disoproxil fumarate (HPLC Purity: 99.8%).

1. temperaturemaintained for 20 minutes
2. temperatureThe reaction mass is cooled to 25-30° C.
3. temperatureis cooled to 0-5° C.
4. stirringstirred for 1 hour at 0-5° C
5. filtrationFiltered the material
6. washwashed with isopropyl alcohol (2 ml)
7. washfinally washed with hexane