Sodium Hydroxide → HCID 59302986, compound

HRID 1692143Notes

Reaction equation

C[O:2][C:3](=[O:32])[C:4]1[CH:9]=[CH:8][C:7]([NH:10][S:11]([C:14]2[CH:19]=[CH:18][C:17]([C:20]([CH3:23])([CH3:22])[CH3:21])=[CH:16][CH:15]=2)(=[O:13])=[O:12])=[C:6]([C:24]2[N:28]([CH3:29])[C:27]([CH2:30][CH3:31])=[N:26][N:25]=2)[CH:5]=1.[OH-].[Na+]>C1COCC1>[C:20]([C:17]1[CH:18]=[CH:19][C:14]([S:11]([NH:10][C:7]2[CH:8]=[CH:9][C:4]([C:3]([OH:32])=[O:2])=[CH:5][C:6]=2[C:24]2[N:28]([CH3:29])[C:27]([CH2:30][CH3:31])=[N:26][N:25]=2)(=[O:12])=[O:13])=[CH:15][CH:16]=1)([CH3:23])([CH3:22])[CH3:21]

Participants

Conditions

Temperature: 60 °C

Procedure

A 10 mL scintillation vial was charged with 4-(4-tert-butyl-benzenesulfonylamino)-3-(5-ethyl-4-methyl-4H-[1,2,4]triazol-3-yl)-benzoic acid methyl ester (20 mg, 0.044 mmol) and 3 M NaOH (aq)/THF (1:3) (1.5 mL). The reaction was heated to 60° C. and stirred overnight. The following day, the volatiles were removed in vacuo to about 200 μL at which point the solution was purified by preparative TLC to afford 4-(4-tert-butyl-benzenesulfonylamino)-3-(5-ethyl-4-methyl-4H-[1,2,4]triazol-3-yl)-benzoic acid as a light yellow solid: MS (ES) M+H expect 443.2, found 443.4.

Workup

customThe following day, the volatiles were removed in vacuo to about 200 μL at which point the solution
customwas purified by preparative TLC

Sources & evidence

ORD record: ord-15a35b1996df427b92aedcdbc549da79
Source dataset: uspto-grants-2012_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08153818B2

Reaction notes

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