Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ethanol → 4-formyl-3-(trifluoromethyl)-N-[(trimethylsilyl)methyl]benzamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ethanol | HCID 702 | — |
| 반응물 | 4-(dibromomethyl)-3-(trifluoromethyl)-N-[(trimethylsilyl)methyl]benzamide | HCID 58270976 | — |
| 촉매 | Silver Nitrate | HCID 24470 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | tert-Butyl methyl ether | HCID 15413 | — |
| 생성물 | 4-formyl-3-(trifluoromethyl)-N-[(trimethylsilyl)methyl]benzamide | HCID 58270963 | 100% |
반응 단계
4-(dibromomethyl)-3-(trifluoromethyl)-N-[(trimethylsilyl)methyl]benzamide (22.0 g, 49.1 mmol) and AgNO3 (16.7 g, 98.3 mmol) in EtOH and H2O were refluxed for 2 hours, then diluted with t-BuOMe and washed with brine. Dried over MgSO4 and evaporation yielded the product (15.0 g, 100%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08158560B2 |
| 출처 데이터셋 | uspto-grants-2012_04 |
| ORD ID | ord-1ca7e09e8e2c414e8d8012fe4afeb266 |
| 출처 메모 | uspto-grants-2012_04 |