HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydroxyamine hydrochloride → 4-[(E)-hydroxyiminomethyl]-3-(trifluoromethyl)-N-(trimethylsilylmethyl)benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydroxyamine hydrochloride | HCID 443297 | — |
| Reactant | Sodium Acetate | HCID 517045 | — |
| Reactant | 4-formyl-3-(trifluoromethyl)-N-[(trimethylsilyl)methyl]benzamide | HCID 58270963 | — |
| Solvent | Ethanol | HCID 702 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | tert-Butyl methyl ether | HCID 15413 | — |
| Product | 4-[(E)-hydroxyiminomethyl]-3-(trifluoromethyl)-N-(trimethylsilylmethyl)benzamide | HCID 58270977 | — |
Reaction Steps
4-Formyl-3-(trifluoromethyl)-N-[(trimethylsilyl)methyl]benzamide (15.0 g, 49.4 mmol), Hydroxylamine hydrochloride (6.9 g, 98.8 mmol) and sodium acetate (6.1 g, 74.1 mmol) in EtOH and H2O were stirred at room temperature over night. The reaction mixture was diluted with t-BuOMe, and washed with brine and dried over MgSO4. After evaporation the product was found to be 15.0 g (95%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08158560B2 |
| Source dataset | uspto-grants-2012_04 |
| ORD ID | ord-0a4f8dce19584fb0bf11030d3c91fb9e |
| Source note | uspto-grants-2012_04 |