反应详情

To a stirring solution of psoromic acid (1 mmol) in ethanol (25 mL) was added 2-amino-ethanol (1 mmol). The reaction was stirred for half an hour. The reaction was added with sodium borohydride (4 mmol) under ice bath, and stirred for additional 15 min under ice bath and then allowed to react overnight at room temperature. Water (3 mL) was added, the solution was acidified to a pH of 6 with dilute HCl. All of the solvent was removed by rotary evaporation. The residue was redissolved in ethanol and dried over anhydrous magnesium sulfate, filtered, and evaporated by a rotary evaporator to give a white solid product.

1. stirringstirred for additional 15 min under ice bath
2. customto react overnight at room temperature
3. customAll of the solvent was removed by rotary evaporation
4. dissolutionThe residue was redissolved in ethanol
5. dry with materialdried over anhydrous magnesium sulfate
6. filtrationfiltered
7. customevaporated by a rotary evaporator
8. customto give a white solid product