2-(2-Benzyloxy-phenoxy)-benzoic acid benzyl ester → 2-(2-Hydroxyphenoxy)benzoic acid

HRID 1692637Notes

Reaction equation

HRID 1692637 reaction equation
C([O:8][C:9](=[O:31])[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=1[O:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=1[O:23]CC1C=CC=CC=1)C1C=CC=CC=1>C(O)C.[Pd]>[OH:23][C:18]1[CH:19]=[CH:20][CH:21]=[CH:22][C:17]=1[O:16][C:11]1[CH:12]=[CH:13][CH:14]=[CH:15][C:10]=1[C:9]([OH:31])=[O:8]

Participants

4

Reactant 1

HCID 672803582-(2-Benzyloxy-phenoxy)-benzoic acid benzyl ester

Product 1

HCID 6113882-(2-Hydroxyphenoxy)benzoic acid

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

2-(2-Benzyloxy-phenoxy)-benzoic acid benzyl ester (440 mg, 1 mmol) was dissolved in ethanol (30 mL), and 10% palladium on carbon (44 mg) was added. The mixture was stirred overnight under nitrogen protection. The suspension was filtered, evaporated by a rotatory evaporator to produce 2-(2-hydroxy-phenoxy)-benzoic acid.

Workup

  1. filtrationThe suspension was filtered
  2. customevaporated by a rotatory evaporator

Sources & evidence

ORD record
ord-53784206bed64b3282dace63542f0e17
Source dataset
uspto-grants-2012_04
Patent number
US08158623B2

Reaction notes

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