反应详情

温度

146.5 °C

2-(2-Hydroxy-phenoxy)-benzoic acid (200 mg) was dissolved in acetic anhydride (10 ml) and refluxed at 145-148° C. for 8 h. The excess acetic anhydride was evaporated by a rotatory evaporator and the residue was poured into ice water. The mixture was extracted with diethyl ether. The organic layer was successively washed with saturated NaHCO3 and saturated ammonium chloride, dried over anhydrous MgSO4, filtered and evaporated by a rotatory evaporator. After dryness and purification by column chromatography, the final product was provided.

1. customThe excess acetic anhydride was evaporated by a rotatory evaporator
2. additionthe residue was poured into ice water
3. extractionThe mixture was extracted with diethyl ether
4. washThe organic layer was successively washed with saturated NaHCO3 and saturated ammonium chloride
5. dry with materialdried over anhydrous MgSO4
6. filtrationfiltered
7. customevaporated by a rotatory evaporator
8. customAfter dryness and purification by column chromatography