2-(2-Hydroxyphenoxy)benzoic acid → 11H-Dibenzo(b,e)(1,4)dioxepin-11-one

Participants

Reaction Conditions

Reaction Steps

2-(2-Hydroxy-phenoxy)-benzoic acid (200 mg) was dissolved in acetic anhydride (10 ml) and refluxed at 145-148° C. for 8 h. The excess acetic anhydride was evaporated by a rotatory evaporator and the residue was poured into ice water. The mixture was extracted with diethyl ether. The organic layer was successively washed with saturated NaHCO3 and saturated ammonium chloride, dried over anhydrous MgSO4, filtered and evaporated by a rotatory evaporator. After dryness and purification by column chromatography, the final product was provided.

Provenance & Evidence