Boron Trichloride → HCID 67280782, compound

HRID 1692641Notes

Reaction equation

HRID 1692641 reaction equation
B(Cl)(Cl)Cl.CO[C:7](=[O:25])[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=1[O:14][C:15]1[CH:20]=[CH:19][C:18]([O:21][CH3:22])=[CH:17][C:16]=1[O:23]C>ClCCl>[CH3:22][O:21][C:18]1[CH:19]=[CH:20][C:15]2[O:14][C:9]3[CH:10]=[CH:11][CH:12]=[CH:13][C:8]=3[C:7](=[O:25])[O:23][C:16]=2[CH:17]=1

Participants

4

Reactant 2

HCID 25135Boron TrichlorideHCID 67280560HCID 67280560, compound

Product 1

HCID 67280782HCID 67280782, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

A solution of boron trichloride (1 ml of 1 mol/L solution in dichloromethane) in dichloromethane (2 ml) was added to a stirred solution of 2-(2,4-dimethoxy-phenoxy)-benzoic acid methyl ester (0.364 g) in dichloromethane (15 ml) under ice bath. The solution was stirred for 20 min and then stirred at room temperature for 2 h. The solution was carefully poured into ice water and the crude product was extracted with dichloromethane, washed with saturated brine, dried over anhydrous MgSO4, filtered and evaporated by a rotary evaporator to obtain the product, which was purified by column chromatography.

Workup

  1. stirringstirred at room temperature for 2 h
  2. extractionthe crude product was extracted with dichloromethane
  3. washwashed with saturated brine
  4. dry with materialdried over anhydrous MgSO4
  5. filtrationfiltered
  6. customevaporated by a rotary evaporator
  7. customto obtain the product, which
  8. customwas purified by column chromatography

Sources & evidence

ORD record
ord-666d840f77d345fdbfe57ec793c2f55b
Source dataset
uspto-grants-2012_04
Patent number
US08158623B2

Reaction notes

Loading…