HuagongsheHuagongshe Chemistry Print Report · For research reference only
1H-Indole-4-boronic acid → 2-(9-(2-hydroxyethyl)-2-(1H-indol-4-yl)-6-morpholino-9H-purin-8-yl)propan-2-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1H-Indole-4-boronic acid | HCID 2763173 | — |
| Reactant | 2-(2-Chloro-8-(2-hydroxypropan-2-yl)-6-morpholino-9H-purin-9-yl)ethyl acetate | HCID 58015224 | — |
| Product | 2-(9-(2-hydroxyethyl)-2-(1H-indol-4-yl)-6-morpholino-9H-purin-8-yl)propan-2-ol | HCID 44477428 | — |
Reaction Steps
2-(2-Chloro-8-(2-hydroxypropan-2-yl)-6-morpholino-9H-purin-9-yl)ethyl acetate (165 mg) was treated with indole-4-boronic acid via General Procedure A and purified via reverse phase HPLC to give 21 mg of 101 as a white solid. MS (Q1) 423.2 (M)+
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08158624B2 |
| Source dataset | uspto-grants-2012_04 |
| ORD ID | ord-1b65b8eb10e545c9a7f6f65acc950ac0 |
| Source note | uspto-grants-2012_04 |