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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1692676Generated: November 2, 2026

(2-Aminopyrimidin-5-yl)boronic acid → 5-(9-methyl-6-morpholino-9H-purin-2-yl)pyrimidin-2-amine

https://huagongshe.com/reaction/1692676

Reaction equation

Participants

RoleNameHCIDCharge
Reactant(2-Aminopyrimidin-5-yl)boronic acidHCID 17750211—
Reactant2-Chloro-9-methyl-6-(4-morpholinyl)-9H-purineHCID 71500687—
Product5-(9-methyl-6-morpholino-9H-purin-2-yl)pyrimidin-2-amineHCID 44543764—

Reaction Steps

4-(2-Chloro-9-methyl-9H-purin-6-yl)morpholine (95 mg) was reacted with 2-aminopyrimidine-5-boronic acid, pinacol ester via General Procedure A and purified via reverse phase HPLC to give 26.1 mg of 127 as a white solid. MS (Q1) 313.2 (M)+

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08158624B2
Source datasetuspto-grants-2012_04
ORD IDord-5ddf4a9ef91b4b4ababdc2b4929477b1
Source noteuspto-grants-2012_04