Piperazin-2-one → 4-(2-(2-(3-hydroxyphenyl)-6-morpholino-9H-purin-9-yl)acetyl)piperazin-2-one

HRID 1692691Notes

Reaction equation

HRID 1692691 reaction equation
[OH:1][C:2]1[CH:3]=[C:4]([C:8]2[N:16]=[C:15]3[C:11]([N:12]=[CH:13][N:14]3[CH2:17][C:18]([OH:20])=O)=[C:10]([N:21]3[CH2:26][CH2:25][O:24][CH2:23][CH2:22]3)[N:9]=2)[CH:5]=[CH:6][CH:7]=1.[NH:27]1[CH2:32][CH2:31][NH:30][CH2:29][C:28]1=[O:33]>>[OH:1][C:2]1[CH:3]=[C:4]([C:8]2[N:16]=[C:15]3[C:11]([N:12]=[CH:13][N:14]3[CH2:17][C:18]([N:30]3[CH2:31][CH2:32][NH:27][C:28](=[O:33])[CH2:29]3)=[O:20])=[C:10]([N:21]3[CH2:22][CH2:23][O:24][CH2:25][CH2:26]3)[N:9]=2)[CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 231360Piperazin-2-oneHCID 669098142-(2-(3-hydroxyphenyl)-6-morpholino-9H-purin-9-yl)acetic acid

Product 1

HCID 445439874-(2-(2-(3-hydroxyphenyl)-6-morpholino-9H-purin-9-yl)acetyl)piperazin-2-one

Procedure

Crude 2-(2-(3-hydroxyphenyl)-6-morpholino-9H-purin-9-yl)acetic acid (50 mg) was reacted with piperazin-2-one via General Procedure F and purified via reverse phase HPLC to give 1.9 mg of 139 as a white solid. MS (Q1) 438.2 (M)+

Workup

  1. custompurified via reverse phase HPLC

Sources & evidence

ORD record
ord-74fdecfba6004179be928f06f3ad501d
Source dataset
uspto-grants-2012_04
Patent number
US08158624B2

Reaction notes

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