Morpholine → 5-Chloro-7-(morpholin-4-yl)[1,3]thiazolo[4,5-d]pyrimidine

HRID 1692732Notes

Reaction equation

HRID 1692732 reaction equation
[Cl:1][C:2]1[N:3]=[C:4](Cl)[C:5]2[S:10][CH:9]=[N:8][C:6]=2[N:7]=1.[NH:12]1[CH2:17][CH2:16][O:15][CH2:14][CH2:13]1>CO>[Cl:1][C:2]1[N:3]=[C:4]([N:12]2[CH2:17][CH2:16][O:15][CH2:14][CH2:13]2)[C:5]2[S:10][CH:9]=[N:8][C:6]=2[N:7]=1

Participants

4

Reactant 2

HCID 8083MorpholineHCID 569495425,7-Dichlorothiazolo[4,5-d]pyrimidine

Product 1

HCID 576854145-Chloro-7-(morpholin-4-yl)[1,3]thiazolo[4,5-d]pyrimidine

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A mixture of 5,7-dichlorothiazolo[4,5-d]pyrimidine 42, morpholine (8.11 mL, 2.2 eq.) and MeOH (150 mL) was stirred at room temperature for 1 h. The reaction mixture was then filtered, washed with water and MeOH, to yield 4-(5-chlorothiazolo[4,5-d]pyrimidin-7-yl)morpholine 16 as a white solid.

Workup

  1. filtrationThe reaction mixture was then filtered
  2. washwashed with water and MeOH

Sources & evidence

ORD record
ord-ba42e74c7d4f4f0283d12261a1ec63a2
Source dataset
uspto-grants-2012_04
Patent number
US08158626B2

Reaction notes

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