Morpholine → 5-Chloro-7-(morpholin-4-yl)[1,3]thiazolo[4,5-d]pyrimidine

Participants

Reaction Steps

A mixture of 5,7-dichlorothiazolo[4,5-d]pyrimidine 42, morpholine (8.11 mL, 2.2 eq.) and MeOH (150 mL) was stirred at room temperature for 1 h. The reaction mixture was then filtered, washed with water and MeOH, to yield 4-(5-chlorothiazolo[4,5-d]pyrimidin-7-yl)morpholine 16 as a white solid.

Provenance & Evidence