反应详情

To a solution of 1-(ethylsulfonyl)-3-[4-(7-[2-(trimethylsilyl)ethoxy]methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]azetidin-3-ylacetonitrile (0.111 g, 0.22 mmol) in methylene chloride (3 mL) was added trifluoroacetic acid (2 mL) and the solution was stirred for 1.5 hours. The solvents were removed in vacuo and the residue was dissolved in methanol (3 mL) and ethylenediamine (0.1 mL) was added. After stirring for 3 hours, the volume was reduced in vacuo and the product was purified by preparative-HPLC/MS, (SunFire C18 column, eluting with a gradient of MeCN/H2O containing 0.1% TFA) to afford the product as the trifluoroacetic acid salt (50 mg, 47%).

1. customThe solvents were removed in vacuo
2. dissolutionthe residue was dissolved in methanol (3 mL)
3. additionethylenediamine (0.1 mL) was added
4. stirringAfter stirring for 3 hours
5. customthe product was purified by preparative-HPLC/MS, (SunFire C18 column
6. washeluting with a gradient of MeCN/H2O containing 0.1% TFA)