反应详情

温度

135 °C

A mixture of 2-methylbenzothiazole (1.49 g, 10 mmol) and 1,4-butane sultone (4.0 g, 30 mmol) was heated in a pressure tube at 130-140° C. for 3 hours. The mixture was allowed to cool to room temperature, and the resulting mass was triturated with ethyl acetate (50 ml) until a gray solid separated. The solid was collected by centrifugation, washed with ethyl acetate and dried under vacuum to yield 2.8 g (96%) of Compound 1.

1. temperatureto cool to room temperature
2. customthe resulting mass was triturated with ethyl acetate (50 ml) until a gray solid
3. customseparated
4. customThe solid was collected by centrifugation
5. washwashed with ethyl acetate
6. customdried under vacuum