Methanol → 2-(2,2,2-Trifluoro-1,1-dimethyl-ethyl)-quinoline-6-carboxylic acid

HRID 1693076노트

반응식

HRID 1693076 반응식
CO.[F:3][C:4]([F:23])([F:22])[C:5]([C:8]1[CH:17]=[CH:16][C:15]2[C:10](=[CH:11][CH:12]=[C:13]([C:18]([O:20]C)=[O:19])[CH:14]=2)[N:9]=1)([CH3:7])[CH3:6].[OH-].[Na+]>C1COCC1>[F:23][C:4]([F:3])([F:22])[C:5]([C:8]1[CH:17]=[CH:16][C:15]2[C:10](=[CH:11][CH:12]=[C:13]([C:18]([OH:20])=[O:19])[CH:14]=2)[N:9]=1)([CH3:7])[CH3:6]

참가 물질

5

반응물 3

HCID 887MethanolHCID 14798Sodium HydroxideHCID 57458169Methyl 2-(2,2,2-trifluoro-1,1-dimethylethyl)quinoline-6-carboxylate

생성물 1

HCID 574581632-(2,2,2-Trifluoro-1,1-dimethyl-ethyl)-quinoline-6-carboxylic acid수율 99.8%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

A methanol (6 ml) and THF (6 ml) solution of methyl 2-(2,2,2-trifluoro-1,1-dimethylethyl)quinoline-6-carboxylate (777 mg, 2.6 mmol) and 2M sodium hydroxide aqueous solution (2.6 ml, 5.2 mmol) was treated in the procedure described in Step C-2C to furnish the title compound (735 mg, 99% yield) as a white solid. 1H NMR (300 MHz, CDCl3) δ 1.75 (6H, s), 7.74 (1H, d, J=8.8 Hz), 8.19 (1H, d, J=8.8 Hz), 8.29 (1H, d, J=8.8 Hz), 8.35-8.40 (1H, m), 8.69-8.70 (1H, m). MS (ESI): m/z 284 (M+H)+.

출처 및 근거

ORD 기록
ord-592027b607144ebe9d32c185f59bc213
출처 데이터셋
uspto-grants-2012_04
특허 번호
US08158650B2

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