5-Fluoro-3-methylbenzo[b]thiophene-2-sulphonyl chloride → HCID 59759963, compound

HRID 1693111Notes

Reaction equation

HRID 1693111 reaction equation
[Br:1][C:2]1[CH:8]=[CH:7][C:5]([NH2:6])=[C:4]([CH2:9][CH3:10])[CH:3]=1.[F:11][C:12]1[CH:25]=[CH:24][C:15]2[S:16][C:17]([S:20](Cl)(=[O:22])=[O:21])=[C:18]([CH3:19])[C:14]=2[CH:13]=1>N1C=CC=CC=1>[Br:1][C:2]1[CH:8]=[CH:7][C:5]([NH:6][S:20]([C:17]2[S:16][C:15]3[CH:24]=[CH:25][C:12]([F:11])=[CH:13][C:14]=3[C:18]=2[CH3:19])(=[O:22])=[O:21])=[C:4]([CH2:9][CH3:10])[CH:3]=1

Participants

4

Reactant 2

HCID 27745865-Fluoro-3-methylbenzo[b]thiophene-2-sulphonyl chlorideHCID 28012834-Bromo-2-ethylaniline

Product 1

HCID 59759963HCID 59759963, compoundYield 46.6%

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

This compound was prepared in analogy to Example 1, starting from 4-bromo-2-ethylaniline (CAS:45762-41-2, 2.0 g) and 5-fluoro-3-methylbenzo[b]thiophene-2-sulphonyl chloride (0.265 g) in pyridine (2.0 ml) for 4 h to obtain the desired compound (0.20 g) as a colorless solid. MS (ISP): 445.0, 447.0 (M+NH4)+

Workup

  1. customThis compound was prepared in analogy to Example 1

Sources & evidence

ORD record
ord-36b00e917fa641559f85449afd0c9ec9
Source dataset
uspto-grants-2012_04
Patent number
US08158655B2

Reaction notes

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