4-Bromo-2-(trifluoromethyl)aniline → HCID 59759981, compound

HRID 1693131Notes

Reaction equation

HRID 1693131 reaction equation
[C:1]([O:5][C:6]([N:8]1[C:16]2[C:11](=[CH:12][C:13]([F:17])=[CH:14][CH:15]=2)[C:10]([CH3:18])=[C:9]1[S:19](Cl)(=[O:21])=[O:20])=[O:7])([CH3:4])([CH3:3])[CH3:2].[NH2:23][C:24]1[CH:29]=[CH:28][C:27]([Br:30])=[CH:26][C:25]=1[C:31]([F:34])([F:33])[F:32]>N1C=CC=CC=1>[C:1]([O:5][C:6]([N:8]1[C:16]2[C:11](=[CH:12][C:13]([F:17])=[CH:14][CH:15]=2)[C:10]([CH3:18])=[C:9]1[S:19](=[O:21])(=[O:20])[NH:23][C:24]1[CH:29]=[CH:28][C:27]([Br:30])=[CH:26][C:25]=1[C:31]([F:34])([F:32])[F:33])=[O:7])([CH3:4])([CH3:3])[CH3:2]

Participants

4

Reactant 2

HCID 679604-Bromo-2-(trifluoromethyl)anilineHCID 59759976HCID 59759976, compound

Product 1

HCID 59759981HCID 59759981, compoundYield 20.7%

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

This compound was prepared in analogy to Example 1 starting from 2-chlorosulfonyl-5-fluoro-3-methyl-indole-1-carboxylic acid tert-butyl ester (0.29 g) and 2-amino-5-bromobenzotrifluoride (2.0 g) in pyridine (5 ml) by stirring for 7 days at rt to obtain the title compound (0.095 g) as a colorless foam. MS (ISN): 551.4, 549.3 (M−H)−

Sources & evidence

ORD record
ord-476bdf56e4ae4f3598ae91a977ebbf96
Source dataset
uspto-grants-2012_04
Patent number
US08158655B2

Reaction notes

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