Hydrogen chloride-ethyl acetate → HCID 67280993, compound

HRID 1693133Notes

Reaction equation

HRID 1693133 reaction equation
C(OC([N:8]1[C:16]2[C:11](=[CH:12][C:13]([F:17])=[CH:14][CH:15]=2)[C:10]([CH3:18])=[C:9]1[S:19](=[O:38])(=[O:37])[NH:20][C:21]1[CH:26]=[CH:25][C:24]([C:27]2[CH:32]=[CH:31][N:30]=[CH:29][CH:28]=2)=[CH:23][C:22]=1[C:33]([F:36])([F:35])[F:34])=O)(C)(C)C.[ClH:39].C(OCC)(=O)C>>[ClH:39].[N:30]1[CH:29]=[CH:28][C:27]([C:24]2[CH:25]=[CH:26][C:21]([NH:20][S:19]([C:9]3[NH:8][C:16]4[C:11]([C:10]=3[CH3:18])=[CH:12][C:13]([F:17])=[CH:14][CH:15]=4)(=[O:37])=[O:38])=[C:22]([C:33]([F:36])([F:35])[F:34])[CH:23]=2)=[CH:32][CH:31]=1

Participants

3

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 59759984HCID 59759984, compound

Product 1

HCID 67280993HCID 67280993, compound

Procedure

This compound was prepared in analogy to example 27b starting from 5-fluoro-3-methyl-2-(4-pyridin-4-yl-2-trifluoromethyl-phenylsulfamoyl)-indole-1-carboxylic acid tert-butyl ester (0.052 g), 2.5 N HCl/ethyl acetate (10.0 ml) to obtain the title compound (0.041 g) as a brownish amorphous powder. MS (ISN): 448.4 (M−H)−

Workup

  1. customThis compound was prepared in analogy to example 27b

Sources & evidence

ORD record
ord-bb3adfc703db421a92d245e88f37ee69
Source dataset
uspto-grants-2012_04
Patent number
US08158655B2

Reaction notes

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