反应详情

To a solution of 5-fluoro-3-methyl-indole (CAS: 392-13-2, 2.5 g) in DMF (20 ml) was added potassium hydroxide (1.41 g). The suspension was stirred at rt for 1 h and iodomethane (2.85 g) was added dropwise at 0-5° C. The reaction mixture was stirred at rt for 18 h and concentrated under high vacuum. The residue was quenched with water and extracted with ethyl acetate. The organics were washed, dried and concentrated. The crude residue was chromatographed on silica gel using heptane/ethyl acetate as eluent to obtain the desired compound (2.15 g) as a colorless liquid. MS (EI): 163.1 (M)

1. stirringThe reaction mixture was stirred at rt for 18 h
2. concentrationconcentrated under high vacuum
3. customThe residue was quenched with water
4. extractionextracted with ethyl acetate
5. washThe organics were washed
6. customdried
7. concentrationconcentrated
8. customThe crude residue was chromatographed on silica gel