4-Bromo-2-(trifluoromethyl)aniline → HCID 59759973, compound

HRID 1693135Notes

Reaction equation

HRID 1693135 reaction equation
[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[N:7]([CH3:11])[C:6]([S:12](Cl)(=[O:14])=[O:13])=[C:5]2[CH3:16].[NH2:17][C:18]1[CH:23]=[CH:22][C:21]([Br:24])=[CH:20][C:19]=1[C:25]([F:28])([F:27])[F:26]>N1C=CC=CC=1>[Br:24][C:21]1[CH:22]=[CH:23][C:18]([NH:17][S:12]([C:6]2[N:7]([CH3:11])[C:8]3[C:4]([C:5]=2[CH3:16])=[CH:3][C:2]([F:1])=[CH:10][CH:9]=3)(=[O:14])=[O:13])=[C:19]([C:25]([F:26])([F:27])[F:28])[CH:20]=1

Participants

4

Reactant 2

HCID 679604-Bromo-2-(trifluoromethyl)anilineHCID 59759982HCID 59759982, compound

Product 1

HCID 59759973HCID 59759973, compoundYield 65.9%

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

This compound was prepared in analogy to Example 1 starting from 5-fluoro-1,3-dimethyl-1H-indole-2-sulfonyl chloride (0.25 g) and 2-amino-5-bromobenzotrifluoride (2.3 g) in pyridine (5 ml) for 18 h at 35° C. to obtain the title compound (0.293 g) as a yellow solid. MS (ISN): 551.4, 549.3 (M−H)−

Sources & evidence

ORD record
ord-c3c6e5fba4ba417b8a0c3fd3bf0c5625
Source dataset
uspto-grants-2012_04
Patent number
US08158655B2

Reaction notes

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