反应详情

Trifluoroacetic acid (1 mL) was added to a solution of t-butyl 5-difluoromethylpyrazine-2-carboxylate (175 mg) in dichloromethane (1 mL), and the mixture was stirred at room temperature for five hours. Ether and 5 N sodium hydroxide were added to the reaction solution. The aqueous layer was separated and made acidic with 5 N hydrochloric acid. Ethyl acetate was added to the aqueous layer, and the organic layer was separated. The organic layer was dried over anhydrous magnesium sulfate, and the insoluble matter was separated by filtration. The filtrate was concentrated to obtain the title compound (100 mg).

1. customThe aqueous layer was separated
2. additionEthyl acetate was added to the aqueous layer
3. customthe organic layer was separated
4. dry with materialThe organic layer was dried over anhydrous magnesium sulfate
5. customthe insoluble matter was separated by filtration
6. concentrationThe filtrate was concentrated