Hydrochloric Acid → HCID 57827400, compound

HRID 1693229Notes

Reaction equation

HRID 1693229 reaction equation
[OH-].[Na+].[CH2:3]([O:5][C:6]([C:8]1[CH:9]=[CH:10][C:11]([C:14]([O:16]CC)=[O:15])=[N:12][CH:13]=1)=[CH2:7])[CH3:4].Cl>C(O)C>[CH2:3]([O:5][C:6]([C:8]1[CH:9]=[CH:10][C:11]([C:14]([OH:16])=[O:15])=[N:12][CH:13]=1)=[CH2:7])[CH3:4]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 57827782HCID 57827782, compound

Product 1

HCID 57827400HCID 57827400, compoundYield 105.4%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A 5 N sodium hydroxide solution (2 mL) was added to a solution of ethyl 5-(1-ethoxyvinyl)pyridine-2-carboxylate (100 mg) in ethanol (5 mL). The mixture was stirred at room temperature for two hours. After confirming completion of the reaction, the reaction solution was neutralized with 1 N hydrochloric acid. The aqueous layer was extracted with ethyl acetate, and the organic layer was dried over anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure to obtain the title compound (92 mg).

Workup

  1. customcompletion of the reaction
  2. extractionThe aqueous layer was extracted with ethyl acetate
  3. dry with materialthe organic layer was dried over anhydrous magnesium sulfate
  4. customThe solvent was evaporated under reduced pressure

Sources & evidence

ORD record
ord-1c784a6403324a02a0970215d3e90e37
Source dataset
uspto-grants-2012_04
Patent number
US08158620B2

Reaction notes

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