反应详情

A mixture composed of the above crude 1-(2-amino-4,6-dichloropyrimidin-5-yl)pent-4-en-1-ol (5.06 g), 1,2-dichloroethane (300 mL) and manganese dioxide (20.15 g) was heated under reflux for 15 hours. After confirming that the raw material disappeared, the reaction solution was filtered through Celite, and the filtrate was concentrated under reduced pressure. The resulting residue was purified by silica gel column chromatography (ethyl acetate-chloroform) to obtain the title compound (1.22 g, 24.3%) as a solid.

1. temperaturewas heated
2. temperatureunder reflux for 15 hours
3. filtrationthe reaction solution was filtered through Celite
4. concentrationthe filtrate was concentrated under reduced pressure
5. customThe resulting residue was purified by silica gel column chromatography (ethyl acetate-chloroform)