HCID 86641350, compound → HCID 67280852, compound

HRID 1693317Notes

Reaction equation

HRID 1693317 reaction equation
[CH2:1]([NH:3][CH2:4][CH2:5][C:6]1[C:15]2[CH2:14][S:13][N:12]=[C:11]([NH:16]C(=O)OC(C)(C)C)[C:10]3=[N:24][N:25]([CH2:27][C:28]4[C:33]([CH3:34])=[C:32]([O:35][CH3:36])[C:31]([CH3:37])=[CH:30][N:29]=4)[N:26]=[C:8]([C:9]=23)[CH:7]=1)[CH3:2]>C(OCC)C>[CH2:1]([NH:3][CH2:4][CH2:5][C:6]1[C:15]2[CH2:14][S:13][N:12]=[C:11]([NH2:16])[C:10]3=[N:24][N:25]([CH2:27][C:28]4[C:33]([CH3:34])=[C:32]([O:35][CH3:36])[C:31]([CH3:37])=[CH:30][N:29]=4)[N:26]=[C:8]([C:9]=23)[CH:7]=1)[CH3:2]

Participants

3

Reactant 1

HCID 86641350HCID 86641350, compound

Product 1

HCID 67280852HCID 67280852, compoundYield 32%

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

Synthesis was performed by the same method as in Example 111 using the above tert-butyl {8-[2-(ethylamino)ethyl]-2-[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]-2,7-dihydro-6-thia-1,2,3,5-tetraazabenzo[cd]azulen-4-yl}carbamate (17 mg), followed by trituration with diethyl ether to obtain the title compound (4.4 mg, 31%) as a solid.

Workup

  1. customSynthesis

Sources & evidence

ORD record
ord-0e96657a1fac42a9ba59d57337e1618b
Source dataset
uspto-grants-2012_04
Patent number
US08158638B2

Reaction notes

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