Diisopropylamine → Isohexane ethyl acetate

PdCl2(PPh3)2 (0.026 g, 0.037 mmol) and Cu(I)I (0.007 g, 0.037 mmol) were added sequentially to 5-bromo-1H-pyrrolo[2,3-c]pyridine-2-carboxylic acid ethyl ester (Preparation 26, 0.100 g, 0.370 mmol) under an argon atmosphere. 1,4-Dioxane (7 mL, anhydrous) followed by diisopropylamine (0.063 mL, 0.45 mmol) were added and the stirred mixture was purged with argon for 5 min. Trimethylsilylacetylene (0.064 mL, 0.45 mmol) was added dropwise and the resulting mixture stirred at rt for 24 h. The reaction mixture was partitioned between water (50 mL) and ethyl acetate (100 mL) and the layers separated. The aqueous phase was extracted with ethyl acetate (3×30 mL). The combined organics were washed with brine (50 mL), dried (MgSO4), filtered and concentrated in vacuo. The residue was dissolved in the minimum amount of dichloromethane and loaded onto a silica column. Purification via flash column chromatography (SiO2, dichloromethane then 25% ethyl acetate/isohexane) gave a pale yellow solid. δH (CDCl3): 0.28 (9H, s), 1.43 (3H, t), 4.45 (2H, q), 7.18 (1H, s), 7.83 (1H, s), 8.86 (1H, s), 9.21 (1H, br s).

1. additionwere added
2. customthe stirred mixture was purged with argon for 5 min
3. customThe reaction mixture was partitioned between water (50 mL) and ethyl acetate (100 mL)
4. customthe layers separated
5. extractionThe aqueous phase was extracted with ethyl acetate (3×30 mL)
6. washThe combined organics were washed with brine (50 mL)
7. dry with materialdried (MgSO4)
8. filtrationfiltered
9. concentrationconcentrated in vacuo
10. dissolutionThe residue was dissolved in the minimum amount of dichloromethane
11. customPurification via flash column chromatography (SiO2, dichloromethane

ORD record

ord-1e8aa25591b14e5abaf28e4e5ae589d4

Source dataset

uspto-grants-2012_04

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US08158622B2