Hydrochloric Acid → N-methyloxan-4-amine hydrochloride

HRID 1693401Notes

Reaction equation

HRID 1693401 reaction equation
C([CH2:8][NH:9][CH:10]1[CH2:15][CH2:14][O:13][CH2:12][CH2:11]1)C1C=CC=CC=1.[ClH:16]>CO.CCOCC>[ClH:16].[CH3:8][NH:9][CH:10]1[CH2:15][CH2:14][O:13][CH2:12][CH2:11]1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 29010582Benzylmethyl(tetrahydropyran-4-yl)amine

Product 1

HCID 22736998N-methyloxan-4-amine hydrochloride

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 3283Diethyl EtherSolvent

Procedure

The title compound was prepared according to Preparation 23 from benzylmethyl(tetrahydropyran-4-yl)amine (Preparation 87). Crude material was dissolved in methanol and a solution of 1M HCl in ether was added dropwise to form a precipitate. The product was filtered and washed with ether to give the title compound as the hydrochloride salt as a white crystalline solid. δH (CD3OD): 4.11-4.00 (2H, m), 3.53-3.43 (2H, m), 3.37-3.27 (1H, m), 2.74 (3H, s), 2.11-2.03 (2H, m), 1.74-1.60 (2H, m).

Workup

  1. customThe title compound was prepared
  2. customto form a precipitate
  3. filtrationThe product was filtered
  4. washwashed with ether

Sources & evidence

ORD record
ord-3596797ec9cf4498a8f543bb2f4ededd
Source dataset
uspto-grants-2012_04
Patent number
US08158622B2

Reaction notes

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