N,N-Dimethylpiperidin-4-amine → HCID 59753594, compound

HRID 1693474Notes

Reaction equation

HRID 1693474 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]2[CH:10]=[C:9]([C:11]([NH:13][C@@H:14]([CH2:18][C:19]3[CH:24]=[CH:23][C:22]([F:25])=[CH:21][CH:20]=3)[C:15](O)=[O:16])=[O:12])[NH:8][C:5]2=[CH:6][N:7]=1.[CH3:26][N:27]([CH3:34])[CH:28]1[CH2:33][CH2:32][NH:31][CH2:30][CH2:29]1>>[CH3:26][N:27]([CH3:34])[CH:28]1[CH2:33][CH2:32][N:31]([C:15](=[O:16])[C@@H:14]([NH:13][C:11]([C:9]2[NH:8][C:5]3=[CH:6][N:7]=[C:2]([Cl:1])[CH:3]=[C:4]3[CH:10]=2)=[O:12])[CH2:18][C:19]2[CH:20]=[CH:21][C:22]([F:25])=[CH:23][CH:24]=2)[CH2:30][CH2:29]1

Participants

3

Reactant 2

HCID 417391N,N-Dimethylpiperidin-4-amineHCID 597536992-(S)-[(5-Chloro-1H-pyrrolo[2,3-c]pyridine-2-carbonyl)amino]-3-(4-fluorophenyl)propionic acid

Product 1

HCID 59753594HCID 59753594, compound

Procedure

The title compound was prepared according to EXAMPLE 35 from 2-(S)-[(5-chloro-1H-pyrrolo[2,3-c]pyridine-2-carbonyl)amino]-3-(4-fluorophenyl)propionic acid (EXAMPLE 228) and dimethylpiperidin-4-yl amine (Preparation 90). Purification by preparative HPLC gave the title compound as a yellow crystalline solid. m/z (ES+)=472.34 [M+H]+; RT=2.64 min.

Workup

  1. customThe title compound was prepared
  2. customPurification by preparative HPLC

Sources & evidence

ORD record
ord-ce060b87c3494775b70cf13c025a2e01
Source dataset
uspto-grants-2012_04
Patent number
US08158622B2

Reaction notes

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