反应详情

To a solution of 5-chloro-1H-pyrrolo[2,3-c]pyridine-2-carboxylic acid [1-(S)-(tert-butyldimethylsilanyloxymethyl)-2-oxo-2-phenylethyl]amide (Preparation 101, 220 mg, 0.48 mmol) in THF (10 mL) was added acetic acid (60 μL) and tetrabutylammonium fluoride solution (1 ml, 1M in THF) at rt. After stirring for 3 h the reaction mixture was distributed between ethyl acetate (100 mL) and water (30 mL). The organic layer was separated, then washed with brine (50 ml), dried (MgSO4) and concentrated to a solid residue. Recrystallisation from THF gave the title compound. m/z (ES+)=344.21 [M+H]+; RT=3.02 min.

1. customThe organic layer was separated
2. washwashed with brine (50 ml)
3. dry with materialdried (MgSO4)
4. concentrationconcentrated to a solid residue
5. customRecrystallisation from THF