Trifluoroacetic acid → HCID 57898164, compound

HRID 1693547Notes

Reaction equation

HRID 1693547 reaction equation
C([O:5][C:6](=[O:40])[CH2:7][N:8]1[C:16]2[C:15](=[O:17])[N:14]([C:18]3[CH:23]=[CH:22][C:21]([Cl:24])=[CH:20][CH:19]=3)[C:13]([C:25]3[CH:30]=[CH:29][C:28]([CH:31]([CH3:33])[CH3:32])=[CH:27][CH:26]=3)=[N:12][C:11]=2[C:10]([C:34]2[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=2)=[N:9]1)(C)(C)C.C(O)(C(F)(F)F)=O>C(Cl)Cl>[Cl:24][C:21]1[CH:20]=[CH:19][C:18]([N:14]2[C:15](=[O:17])[C:16]3[N:8]([CH2:7][C:6]([OH:40])=[O:5])[N:9]=[C:10]([C:34]4[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=4)[C:11]=3[N:12]=[C:13]2[C:25]2[CH:26]=[CH:27][C:28]([CH:31]([CH3:33])[CH3:32])=[CH:29][CH:30]=2)=[CH:23][CH:22]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 57897953HCID 57897953, compound

Product 1

HCID 57898164HCID 57898164, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To [6-(4-chloro-phenyl)-5-(4-isopropyl-phenyl)-7-oxo-3-phenyl-6,7-dihydro-pyrazolo[4,3-d]pyrimidin-1-yl]-acetic acid tert-butyl ester (20.0 mg, 0.036 mmol) are added DCM (0.5 mL) and TFA (0.5 mL), The resultant solution is stirred at room temperature for 4 hours. Removal of the solvent under reduced pressure provides crude [6-(4-chlorophenyl)-5-(4-isopropyl-phenyl)-7-oxo-3-phenyl-6,7-dihydro-pyrazolo[4,3-d]pyrimidin-1-yl]-acetic acid, which is used directly for next reaction without further purification.

Workup

  1. customRemoval of the solvent under reduced pressure

Sources & evidence

ORD record
ord-c7134233e6534024af045961bf8bd76d
Source dataset
uspto-grants-2012_04
Patent number
US08158634B2

Reaction notes

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