Tributyltin Chloride → 4-chloro-3-(4-fluoro-phenyl)-5-tributylstannanyl-1-(2-trimethylsilanyl-ethoxymethyl)-1H-pyrrolo[2,3-b]pyridine

HRID 1693726Notes

Reaction equation

HRID 1693726 reaction equation
Br[C:2]1[C:3]([Cl:26])=[C:4]2[C:10]([C:11]3[CH:16]=[CH:15][C:14]([F:17])=[CH:13][CH:12]=3)=[CH:9][N:8]([CH2:18][O:19][CH2:20][CH2:21][Si:22]([CH3:25])([CH3:24])[CH3:23])[C:5]2=[N:6][CH:7]=1.[Cl-].[Li+].C([Mg]Cl)(C)C.[CH2:34]([Sn:38](Cl)([CH2:43][CH2:44][CH2:45][CH3:46])[CH2:39][CH2:40][CH2:41][CH3:42])[CH2:35][CH2:36][CH3:37].[Cl-].[NH4+]>C1COCC1.C(OCC)C>[Cl:26][C:3]1[C:2]([Sn:38]([CH2:39][CH2:40][CH2:41][CH3:42])([CH2:43][CH2:44][CH2:45][CH3:46])[CH2:34][CH2:35][CH2:36][CH3:37])=[CH:7][N:6]=[C:5]2[N:8]([CH2:18][O:19][CH2:20][CH2:21][Si:22]([CH3:25])([CH3:24])[CH3:23])[CH:9]=[C:10]([C:11]3[CH:16]=[CH:15][C:14]([F:17])=[CH:13][CH:12]=3)[C:4]=12

Participants

8

Reactant 5

HCID 15096Tributyltin ChlorideHCID 25517Ammonium ChlorideHCID 433294Lithium ChlorideHCID 575374765-bromo-4-chloro-3-(4-fluoro-phenyl)-1-(2-trimethylsilanyl-ethoxymethyl)-1H-pyrrolo[2,3-b]pyridineHCID 178418918HCID 178418918, compound

Product 1

HCID 575376414-chloro-3-(4-fluoro-phenyl)-5-tributylstannanyl-1-(2-trimethylsilanyl-ethoxymethyl)-1H-pyrrolo[2,3-b]pyridineYield 121.1%

Reagents, catalysts & solvents 2

HCID 3283Diethyl EtherSolventHCID 8028TetrahydrofuranSolvent2×

Conditions

Temperature
-25 °C

Procedure

1.30 g (2.85 mmol) of 5-bromo-4-chloro-3-(4-fluoro-phenyl)-1-(2-trimethylsilanyl-ethoxymethyl)-1H-pyrrolo[2,3-b]pyridine and 750 mg (17.69 mmol) of anhydrous vacuum dried lithium chloride were dissolved under nitrogen in 50 mL of anhydrous THF. The resulting solution was cooled to −25° C. and 2.0 mL (4 mmol) of a 2 M solution of iso-propyl-magnesium chloride in anhydrous THF was added dropwise. The resulting mixture was allowed to stir at −25 to −5° C. for 2 h. 2.0 mL (7.4 mmol) of tri-n-butyltin chloride was added slowly to the resulting mixture. Upon complete addition the reaction mixture was allowed to stir for 18 h, allowing to warm to ambient temperature. The resulting reaction mixture was distributed between diethyl ether and a saturated aqueous solution of ammonium chloride. The aqueous phase was separated and extracted twice with diethyl ether. The combined organic phases were dried over sodium sulfate and evaporated. The residue was purified by flash chromatography on silica gel using a gradient of ethyl acetate and hexanes to afford 2.298 g (3.45 mmol, 121%) of 4-chloro-3-(4-fluoro-phenyl)-5-tributylstannanyl-1-(2-trimethylsilanyl-ethoxymethyl)-1H-pyrrolo[2,3-b]pyridine as a colorless oil. 1H-NMR [500 MHz, d6-DMSO] δ: 8.13 (s, 1H), 7.77 (s, 1H), 7.49-7.45 (m, 2H), 7.27-7.22 (m, 2H), 5.66 (s, 2H), 3.55 (t, 2H), 1.63-1.47* (m, 6H), 1.34-1.08* (m, 12H), 0.89-0.80* (t, 9H), −0.12 (s, 9H) [*: compound contaminated with other tri-n-butyl tin side product(s) in shift ranges indicated, appearing as distinct sets of peaks with equal integration to desired product]; MS [MH+] m/z: 665+667.

Workup

  1. additionUpon complete addition the reaction mixture
  2. stirringto stir for 18 h
  3. temperatureto warm to ambient temperature
  4. customThe resulting reaction mixture
  5. customThe aqueous phase was separated
  6. extractionextracted twice with diethyl ether
  7. dry with materialThe combined organic phases were dried over sodium sulfate
  8. customevaporated
  9. customThe residue was purified by flash chromatography on silica gel using a gradient of ethyl acetate and hexanes

Sources & evidence

ORD record
ord-9ef78ddd5edb4679bbaba660a9bd4b14
Source dataset
uspto-grants-2012_04
Patent number
US08158647B2

Reaction notes

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