Methanol → (4-(5-Methyl-furan-2-ylmethyl)-phenyl)acetohydroximoyl chloride

To a mixture of 2-methyl-5-(4-(2-nitro-ethyl)-benzyl)-furan (87 mg, 0.36 mmol) described in Manufacturing Example 46-1-5 and methanol (2 mL) was added lithium methoxide (27 mg, 0.71 mmol) at room temperature, which was stirred for 15 minutes at room temperature. The solvent was evaporated from the reaction mixture under a reduced pressure. Titanium (IV) chloride (86 μL, 0.78 mmol) was added at −78° C. to a mixture of the resulting residue, methylene chloride (2 mL) and tetrahydrofuran (1 mL), which was stirred for 1 hour at 0° C. The reaction mixture was cooled to −78° C., water (5 mL) was added, and the temperature was gradually raised to room temperature. The reaction mixture was extracted by addition of ethyl acetate and water. The organic layer was washed with water until the pH became about 5. The organic layer was washed with saturated aqueous sodium chloride and dried over anhydrous magnesium sulfate. Thereafter, the organic layer was filtered and the filtrate was concentrated under a reduced pressure to obtain the title compound (79 mg, 84%).

1. customThe solvent was evaporated from the reaction mixture under a reduced pressure
2. stirringwas stirred for 1 hour at 0° C
3. temperatureThe reaction mixture was cooled to −78° C.
4. temperaturethe temperature was gradually raised to room temperature
5. extractionThe reaction mixture was extracted by addition of ethyl acetate and water
6. washThe organic layer was washed with water until the pH
7. washThe organic layer was washed with saturated aqueous sodium chloride
8. dry with materialdried over anhydrous magnesium sulfate
9. filtrationThereafter, the organic layer was filtered
10. concentrationthe filtrate was concentrated under a reduced pressure

ORD record

ord-05385b787e2c4f59859758af82e3d9f9

Source dataset

uspto-grants-2012_04

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US08158657B2