HCID 67122522, compound → Ciclesonide

HRID 1694533Notes

Reaction equation

HRID 1694533 reaction equation
[CH3:1][CH:2]([C:4]([O:6][CH2:7][C:8]([C@@:10]12[O:33][C@H:32]([CH:34]3[CH2:39][CH2:38][CH2:37][CH2:36][CH2:35]3)[O:31][C@@H:11]1[CH2:12][C@H:13]1[C@@H:18]3[CH2:19][CH2:20][C:21]4[C@@:27]([CH3:28])([C@H:17]3[C@@H:16]([OH:29])[CH2:15][C@@:14]12[CH3:30])[CH:26]=[CH:25][C:23](=[O:24])[CH:22]=4)=[O:9])=[O:5])[CH3:3].CO>O>[CH3:3][CH:2]([C:4]([O:6][CH2:7][C:8]([C@@:10]12[O:33][C@H:32]([CH:34]3[CH2:35][CH2:36][CH2:37][CH2:38][CH2:39]3)[O:31][C@@H:11]1[CH2:12][C@H:13]1[C@@H:18]3[CH2:19][CH2:20][C:21]4[C@@:27]([CH3:28])([C@H:17]3[C@@H:16]([OH:29])[CH2:15][C@@:14]12[CH3:30])[CH:26]=[CH:25][C:23](=[O:24])[CH:22]=4)=[O:9])=[O:5])[CH3:1]

Participants

3

Reactant 1

HCID 67122522HCID 67122522, compound

Product 1

HCID 6918155Ciclesonide

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

In an embodiment, crystalline ciclesonide methanol solvate Form C is stirred in water for a period of time ranging from 1 hour to 6 hours to form a suspension, followed by cooling and isolating solid crystalline anhydrous ciclesonide Form A. Suitably, the stirring takes place at a temperature ranging from 50 to 60° C. Optionally, the isolated solid is dried in a vacuum oven at a temperature above 60° C., more preferably above 90° C.

Workup

  1. waitranging from 1 hour to 6 hours
  2. customto form a suspension
  3. temperatureby cooling

Sources & evidence

ORD record
ord-c20b6938931a4ee488e9f3548ffeb5d4
Source dataset
uspto-grants-2012_04
Patent number
US08158780B2

Reaction notes

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