反应详情

To a −78° C. solution of 5-fluoro-2-formylpyridine (0.66 g, 5.3 mmol) in THF (20 mL) was methyl lithium (1.6 M in diethyl ether, 4.0 mL) added dropwise. After stirring for 1.5 h at −78° C. a saturated solution of ammonium chloride (25 mL) followed by water (25 mL) was added. The mixture was extracted with chloroform and the organic phase was dried over magnesium sulphate and concentrated in vacuo. The residue was purified by flash column chromatography (eluent: chloroform:methanol 98:2) affording the title compound (0.25 g, 33% yield).

1. customTo a −78° C.
2. additionadded dropwise
3. additionwas added
4. extractionThe mixture was extracted with chloroform
5. dry with materialthe organic phase was dried over magnesium sulphate
6. concentrationconcentrated in vacuo
7. customThe residue was purified by flash column chromatography (eluent: chloroform:methanol 98:2)