Trifluoroacetic acid → HCID 59660644, compound

HRID 1694671Notes

Reaction equation

HRID 1694671 reaction equation
[P:1]([O:13][CH2:14][O:15][C:16]1[CH:21]=[CH:20][C:19]([C:22]2[C:31](=[O:32])[C:30]3[C:25](=[CH:26][C:27]([O:33][CH2:34][C:35]4[N:36]=[C:37]([C:40]5[CH:45]=[C:44]([F:46])[CH:43]=[C:42]([C:47]([F:50])([F:49])[F:48])[CH:41]=5)[O:38][CH:39]=4)=[CH:28][CH:29]=3)[O:24][CH:23]=2)=[CH:18][CH:17]=1)([O:8]C(C)(C)C)([O:3]C(C)(C)C)=[O:2].FC(F)(F)C(O)=O>C(Cl)Cl>[P:1]([OH:3])([OH:8])([O:13][CH2:14][O:15][C:16]1[CH:21]=[CH:20][C:19]([C:22]2[C:31](=[O:32])[C:30]3[C:25](=[CH:26][C:27]([O:33][CH2:34][C:35]4[N:36]=[C:37]([C:40]5[CH:45]=[C:44]([F:46])[CH:43]=[C:42]([C:47]([F:50])([F:49])[F:48])[CH:41]=5)[O:38][CH:39]=4)=[CH:28][CH:29]=3)[O:24][CH:23]=2)=[CH:18][CH:17]=1)=[O:2]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86622682HCID 86622682, compound

Product 1

HCID 59660644HCID 59660644, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

In a 50 mL round bottomed flask ditert-butyl {4-[7-({2-[5-fluoro-3-(trifluoromethyl)phenyl](1,3-oxazol-4-yl)}methoxy)-4-oxochromen-3-yl]phenoxy}methyl phosphate (119.1 mg, 0.166 mmol) was treated with trifluoroacetic acid (37.9 mg, 0.332 mmol, 2.0 equiv) in methylene chloride (2 ml). The mixture was stirred at room temperature for 18 hours, methylene chloride (10 ml) added, and the suspension thus obtained was filtered through a glass filter. The residue on the filter was collected to give {4-[7-({2-[5-fluoro-3-(trifluoromethyl)phenyl](1,3-oxazol-4-yl)}methoxy)-4-oxochromen-3-yl]phenoxy}methyl dihydrogen phosphate.

Workup

  1. customthe suspension thus obtained
  2. filtrationwas filtered through a glass
  3. filtrationfilter
  4. customThe residue on the filter was collected

Sources & evidence

ORD record
ord-66d287e8badd4c7cb01b6bf6de31831c
Source dataset
uspto-grants-2012_04
Patent number
US08158810B2

Reaction notes

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