HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → 1-(5-Bromo-4-methyl-2-pyrimidinyl)-3-azetidinol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 3-Hydroxyazetidine hydrochloride | HCID 2759290 | — |
| Reactant | 2,5-Dibromo-4-methylpyrimidine | HCID 66521322 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 1-(5-Bromo-4-methyl-2-pyrimidinyl)-3-azetidinol | HCID 67280143 | — |
Reaction Steps
A mixture of the product from example 135 step (i) (0.75 g), azetidin-3-ol hydrochloride (0.66 g) and triethylamine (0.9 ml) in ethanol (10 ml) was stirred at RT for 2 h. The solvent was removed under reduced pressure and the residue purified by chromatography on silica eluting with 60% diethylether/isohexane as eluant, yield 0.7 g.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08158820B2 |
| Source dataset | uspto-grants-2012_04 |
| ORD ID | ord-7ec627b9c75a4c789e6ada6095f8c5f8 |
| Source note | uspto-grants-2012_04 |