反应详情

A mixture of the product from example 135 step (i) (0.75 g), azetidin-3-ol hydrochloride (0.66 g) and triethylamine (0.9 ml) in ethanol (10 ml) was stirred at RT for 2 h. The solvent was removed under reduced pressure and the residue purified by chromatography on silica eluting with 60% diethylether/isohexane as eluant, yield 0.7 g.

1. customThe solvent was removed under reduced pressure
2. customthe residue purified by chromatography on silica eluting with 60% diethylether/isohexane as eluant